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Minder moe na kanker door aandachtsgerichte cognitieve therapie
Samenvatting
Ongeveer eenderde van de mensen die succesvol zijn behandeld voor kanker blijven langdurig en ernstig vermoeid. In deze studie is onderzocht of ernstige chronische vermoeidheid na kanker vermindert door aandachtsgerichte cognitieve groepstherapie. Deelnemers werden random toegewezen aan een interventie een wachtlijstcontrolegroep. De analyses zijn gebaseerd op 59 deelnemers in de interventiegroep en 24 in de wachtlijstgroep. De ernst van de vermoeidheid (Checklist Individual Strength), de functiebeperkingen (Sickness Impact Profile) en het welbevinden (Health and Disease Inventory) werden voor en na de negen weken durende interventie bepaald. De interventiegroep had zes maanden na de interventie nog een follow-up meting. Het percentage deelnemers aan de interventie met klinische relevante verbeteringen was bij de nameting 30%, versus 4% bij de wachtlijstgroep (χ² (1) = 6,71; p = 0.007). De gemiddelde vermoeidheidsscore bij de nameting was significant lager bij de interventiegroep dan bij de wachtlijstcontrolegroep gecorrigeerd voor het vermoeidheidsniveau voor de behandeling. Welbevinden was significant hoger bij de nameting in de interventiegroep dan in de wachtlijstgroep gecorrigeerd voor niveau van welbevinden voor de behandeling. Het effect van de behandeling bleef bestaan bij de follow-up meting na zes maanden. Er werden tussen de twee groepen geen verschillen gevonden wat betreft functiebeperkingen. Aandachtsgerichte cognitieve therapie lijkt een effectieve behandeling voor chronische vermoeidheid na kanker.
Summary
Mindfulness-based cognitive therapy reduces cancer-related chronic fatigue: a treatment study
Introduction: About one-third of cancer survivors suffer from severe chronic fatigue. Aim of this study was to evaluate the efficacy of mindfulness-based cognitive group therapy in reducing severe chronic fatigue in cancer survivors with mixed diagnoses. Patients and Methods: Participants (n5100) were randomly selected from a cohort and allocated to an intervention and a waiting list condition. Analyses were based on 59 participants in the intervention condition and 24 in the waiting-list condition. Fatigue severity (Checklist Individual Strength), functional impairment (Sickness Impact Profile) and well being (Health and Disease-Inventory) were assessed before and after the 9-week intervention. The intervention group had a follow-up 6 months following the intervention. Results: At post-treatment measurement the proportion of clinically improved participants was 30%, versus 4% in the waiting list condition (v2 (1)56.71; p50.007). The mean fatigue score at post-measurement was significantly lower in the intervention group than in the waiting list group, corrected for pre-treatment level of fatigue. The mean well-being score at postmeasurement was significantly higher in the intervention group than in the waiting list group, corrected for pre-treatment level of well-being. The treatment effect was maintained at 6-month follow-up. No difference between the two conditions was found in functional impairment. Discussion: Mindfulness-based cognitive therapy is an effective treatment for chronic cancerrelated fatigue.
Trefwoorden
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